Alexiel was a beautiful angel who defied God and was reincarnated in the body of 16-year-old Setsuna Mudo, who happens to have incestuous feelings for his sister Sara. Together, they get caught up in a fight between Heaven and Hell.

The year 2071, the Earth has been devastated by mysterious monsters that devour living creatures and are impervious to weapons. An organization called Fenrir is the only one with weapons capable of killing the monsters.

The vampire Alucard, his master Sir Integra Fairbrook Wingates Hellsing, and his newly sired ward Seras Victoria, try to protect England from a war-crazed SS-Major who seeks to start an eternal war with his vampire army.